Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists linked to a collagen-binding domain

Year: 
2012
Principal Investigator:
Robert Gensure, MD, PhD
Sponsoring Institution:
Children’s Hospital at Montefiore

Description

To study parathyroid hormone therapy for alopecia areata.

Significance

The final report shows PTH-CBD is a promising therapy for alopecia areata, particularly in conjunction with a mild immune suppressant, such as hydrocortisone cream. 

Purpose

To test the efficacy of PTH-CBD, a compound that stimulates the hair cycle, in stimulating hair growth in the C3H/HeJ engrafted mouse model of alopecia areata.