The Role for miRNAs in Alopecia Areata

Year: 
2016
Principal Investigator:
Natalia V. Botchkareva, MD, PhD
Sponsoring Institution:
University of Bradford
Principle Investigator

Significance

The identification of the role of micro RNAs (miRNAs) in pathogenesis could lead to novel therapies for alopecia areata.

Purpose

1) To define the role of miR-486 and miR-451 in hair growth and hair follicle immune privilege in normal and affected skin in the mouse model; and 2) To determine the role of miR-486 and miR-451 in the response of human hair follicles to pro-inflammatory cytokines.