Nutraceutical Stimulation of Intrafollicular Autophagy as an Adjuvant Strategy in the Management of Alopecia Areata

Year: 
2019 to 2020
Investigator-Initiated Research Grant Opportunities
Ralf Paus, MD, Principal Investigator
University of Manchester

Significance

If successful, this study may help inform new treatment strategies in alopecia areata through the use commercially available nutraceuticals that target autophagy.

Purpose

This project will explore whether alopecia areata hair follicles display malfunctions in autophagy, which may make them more susceptible to immune-mediated hair follicle damage, and whether promoting hair follicle autophagy with nutraceuticals enhances human hair follicle growth and stress-resistance.