website-header.png

Mechanistic Studies of Interleukin-7 Signaling Pathway in Alopecia Areata

Year: 
2016 to 2019
Zhenpeng Dai, PhD, Principal Investigator
Columbia University

Mentored Young Investigator Grant Opportunities

Significance

If successful, this study will provide valuable information about the role of IL-7 in the onset of alopecia areata and therapeutic potential. Investment in a well-trained young investigator with a multidisciplinary background will likely lead to future alopecia areata research and NIH funding.

Purpose

1) To understand the pathogenic role of IL-7 and its receptor blockade in alopecia areata using the C3H/HeJ mouse model; and 2) To assess IL-7 expression correlation in human alopecia areata skin or blood correlates with disease severity and parallels clinical status.