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Identifying pathogenic T cell receptor sequences in alopecia areata

Year: 
2015 to 2017
Annemieke de Jong, PhD, Principal Investigator
Columbia University

Bridge Grant Opportunities

Significance

This study utilizes Next-Gen technology for DNA sequencing to learn about disease process and potentially establish a biomarker. If successful, findings could be applied to other autoimmune diseases. It is highly innovative and likely to lead to follow-on funding.

Purpose

To determine the T cell receptors of hair follicle infiltrating T cells, and determine their frequency in affected skin, unaffected skin and if they are circulating in the blood.