Identifying pathogenic T cell receptor sequences in alopecia areata

Year: 
2015
Principal Investigator:
Annemieke de Jong, PhD
Sponsoring Institution:
Columbia University

Description

Bridge Grant Opportunities

Significance

This study utilizes Next-Gen technology for DNA sequencing to learn about disease process and potentially establish a biomarker. If successful, findings could be applied to other autoimmune diseases. It is highly innovative and likely to lead to follow-on funding.

Purpose

To determine the T cell receptors of hair follicle infiltrating T cells, and determine their frequency in affected skin, unaffected skin and if they are circulating in the blood.