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Clonotype analysis of alopecia areata-specific CD8 T-lymphocytes

Year: 
2013 to 2015
Investigator-Initiated Research Grant Opportunities
Ralf Paus, MD, Principal Investigator
University of Münster

Significance

This may lead to selective eliminatation of autoaggressive CD8+ T‐cell clones and to identification, in a follow‐up project, of the selfautoantigens that trigger the attack on the hair follicles and may serve as a basis for alopecia areata immunotherapy and prognostic biomarker(s).

Purpose

To characterize the receptors of the autoaggressive T‐cell clones that are responsible for alopecia areata by isolating CD8+ T cells from alopecia areata skin and identify their T‐cell receptor (TCR) chain directly in human skin with alopecia areata lesions.